Publicações

Produção Científica

Explore as nossas publicações científicas e os resultados mais recentes da nossa investigação

2026

The azole-resistance phenotype of a Nakaseomyces glabratus clinical strain encoding a wild-type PDR1 allele involves the efflux pumps Aus1 and Pdh1 and Cyb5, an alternative reductase required for ergosterol biosynthesis

Pinheiro MJ · Parker JE · Ferreira MT · Fernandes F · Mira NP

Microbiology Spectrum · 2026DOI →

2025

Evaluation of antibacterial properties of Lactobacillus acidophilus and Lactobacillus gasseri on enterotoxigenic Escherichia coli associated with porcine post-weaning diarrhea (PWD) using Galleria mellonella model

Araújo D · Silva AR · Silva S · Mira NP · Almeida C · Castro J

The Microbe · 2025DOI →

Vapor phase of white thyme essential oil: effect on Candida albicans and preservation of Lactobacillus species in the context of vulvovaginal candidiasis

Fernandes L · Silva I · Araújo D · Costa R · Silva S · Mira NP · Costa-de-Oliveira S · Henriques M · Rodrigues ME

BMC Complementary Medicine and Therapies · 2025DOI →

The transcription factor CgHaa1 plays a role in virulence of the pathogenic yeast Candida glabrata

Salazar SB · Pedro NA · Silva S · Mil-Homens D · Pimenta A · Wlodarczyk M · Szwed-Georgiou A · Sasamoto K · Chibana H · Michlewska S · Rudnicka K · Fialho A · Mira NP

FEMS Yeast Research · 2025DOI →

2024

Methods for studying microbial acid stress responses: from molecules to populations

Atasoy M · Bartkova S · Çetecioğlu-Gürol Z · Mira NP · O'Byrne C · Pérez-Rodríguez F · Possas A · Scheler O · Sedláková-Kaduková J · Sinčák M · Steiger M · Ziv C · Lund PA

FEMS Microbiology Reviews · 2024DOI →

On the potential role of naturally occurring carboxylic organic acids as anti-infective agents: opportunities and challenges

Mira NP · Marshall R · Pinheiro MJ · Dieckmann R · Al Dahouk SA · Skroza N · Rudnicka K · Lund PA · De Biase D

International Journal of Infectious Diseases · 2024DOI →

A molecular view on the interference established between vaginal Lactobacilli and pathogenic Candida species: Challenges and opportunities for the development of new therapies

Pedro NA · Mira NP

Microbiological Research · 2024DOI →

2023

Insights into the transcriptional regulation of poorly characterized alcohol acetyltransferase-encoding genes (HgAATs) shed light into the production of acetate esters in the wine yeast Hanseniaspora guilliermondii

Seixas I · Santos D · Vasconcelos I · Mira NP · Mendes-Ferreira A

FEMS Yeast Research · 2023DOI →

A Genome-Wide Phenotypic Analysis of Saccharomyces cerevisiae’s Adaptive Response and Tolerance to Chitosan in Conditions Relevant for Winemaking

Lage P · Coelho BB · Mira NP · Mendes-Ferreira A

Fermentation · 2023DOI →

2022

Cyclam-based iron(III) and copper(II) complexes: synthesis, characterization and application as antifungal agents

Almada S · Maia LB · Waerenborgh JC · Vieira BJC · Mira NP · Silva ER · Cerqueira F · Pinto E · Alves LG

New Journal of Chemistry · 2022DOI →

Disclosing azole resistance mechanisms in resistant Candida glabrata strains encoding wild-type or gain-of-function CgPDR1 alleles through comparative genomics and transcriptomics

Salazar SB · Pinheiro MJ · Sotti-Novais D · Soares AR · Lopes MM · Ferreira T · Rodrigues V · Fernandes F · Mira NP

G3: Genes, Genomes, Genetics · 2022DOI →

Integrated perspective on microbe-based production of itaconic acid: From metabolic and strain engineering to upstream and downstream strategies

Nascimento MF · Marques N · Correia J · Faria NT · Mira NP · Ferreira FC

Process Biochemistry · 2022DOI →

2021

Implementation of Synthetic Pathways to Foster Microbe-Based Production of Non-Naturally Occurring Carboxylic Acids and Derivatives

Vila-Santa A · Mendes FC · Ferreira FC · Prather KLJ · Mira NP

Journal of Fungi · 2021DOI →

Bioactive Coatings with Ag-Camphorimine Complexes to Prevent Surface Colonization by the Pathogenic Yeast Candida albicans

Pinheiro MJ · Costa JP · Marques F · Mira NP · Carvalho MFNN · Alves MM

Antibiotics · 2021DOI →

Prospecting Biochemical Pathways to Implement Microbe-Based Production of the New-to-Nature Platform Chemical Levulinic Acid

Vila-Santa A · Islam MA · Ferreira FC · Prather KLJ · Mira NP

ACS Synthetic Biology · 2021DOI →

Genome sequencing, annotation and exploration of the SO₂-tolerant non-conventional yeast Saccharomycodes ludwigii

Tavares MJ · Güldener U · Mendes-Ferreira A · Mira NP

BMC Genomics · 2021DOI →

2020

Understanding How Microorganisms Respond to Acid pH Is Central to Their Control and Successful Exploitation

Lund PA · De Biase D · Liran O · Scheler O · Mira NP · Cetecioglu Z · Noriega Fernández E · Bover-Cid S · Hall R · Sauer M · O’Byrne C

Frontiers in Microbiology · 2020DOI →

Effect of progesterone on Candida albicans biofilm formation under acidic conditions: A transcriptomic analysis

Gonçalves B · Bernardo R · Wang C · Schröder MS · Pedro NA · Butler G · Azeredo J · Henriques M · Mira NP · Silva S

International Journal of Medical Microbiology · 2020DOI →

MOMO - multi-objective metabolic mixed integer optimization: application to yeast strain engineering

Andrade R · Doostmohammadi M · Santos JL · Sagot MF · Mira NP · Vinga S

BMC Bioinformatics · 2020DOI →

Metabolic engineering of an acid-tolerant yeast strain Pichia kudriavzevii for itaconic acid production

Sun W · Vila-Santa A · Liu N · Prozorov T · Xie D · Faria NT · Ferreira FC · Mira NP · Shao Z

Metabolic Engineering Communications · 2020DOI →

An Overview on Conventional and Non-Conventional Therapeutic Approaches for the Treatment of Candidiasis and Underlying Resistance Mechanisms in Clinical Strains

Salazar SB · Simões RS · Pedro NA · Pinheiro MJ · Carvalho MFNN · Mira NP

Journal of Fungi · 2020DOI →

Metabolic specialization in itaconic acid production: a tale of two fungi

Wierckx N · Agrimi G · Lübeck PS · Steiger MG · Mira NP · Punt PJ

Current Opinion in Biotechnology · 2020DOI →

2019

Characterizing the Potential of the Non-Conventional Yeast Saccharomycodes ludwigii UTAD17 in Winemaking

Esteves M · Barbosa C · Vasconcelos I · Tavares MJ · Mendes-Faia A · Mira NP · Mendes-Ferreira A

Microorganisms · 2019DOI →

Transcriptomic and chemogenomic analyses unveil the essential role of Com2-regulon in response and tolerance of Saccharomyces cerevisiae to stress induced by sulfur dioxide

Lage P · Sampaio-Marques B · Ludovico P · Mira NP · Mendes-Ferreira A

Microbial Cell · 2019DOI →

Study of the activity of Punica granatum-mediated silver nanoparticles against Candida albicans and Candida glabrata, alone or in combination with azoles or polyenes

Souza JAS · Alves MM · Barbosa DB · Lopes MM · Pinto E · Figueiral MH · Delbem ACB · Mira NP

Medical Mycology · 2019DOI →

Antimicrobial Activity of Silver Camphorimine Complexes against Candida Strains

Costa JP · Pinheiro MJ · Sousa SA · Botelho do Rego AM · Marques F · Oliveira MC · Leitão JH · Mira NP · Carvalho MFNN

Antibiotics · 2019DOI →

Effect of Acetic Acid and Lactic Acid at Low pH in Growth and Azole Resistance of Candida albicans and Candida glabrata

Lourenço A · Pedro NA · Salazar SB · Mira NP

Frontiers in Microbiology · 2019DOI →

A Transcriptomics Approach To Unveiling the Mechanisms of In Vitro Evolution towards Fluconazole Resistance of a Candida glabrata Clinical Isolate

Cavalheiro M · Costa C · Silva-Dias A · Miranda IM · Wang C · Pais P · Pinto SN · Mil-Homens D · Sato-Okamoto M · Takahashi-Nakaguchi A · Silva RM · Mira NP · Fialho AM · Chibana H · Rodrigues AG · Butler G · Teixeira MC

Antimicrobial Agents and Chemotherapy · 2019DOI →

2018

Genome sequence of the non-conventional wine yeast Hanseniaspora guilliermondii UTAD222 unveils relevant traits of this species and of the Hanseniaspora genus in the context of wine fermentation

Seixas I · Barbosa C · Mendes-Faia A · Güldener U · Tenreiro R · Mendes-Ferreira A · Mira NP

DNA Research · 2018DOI →

Genome Sequence of the Wine Yeast Saccharomycodes ludwigii UTAD17

Tavares MJ · Güldener U · Esteves M · Mendes-Faia A · Mendes-Ferreira A · Mira NP

Microbiology Resource Announcements · 2018DOI →

In silico, in vitro and antifungal activity of the surface layers formed on zinc during this biomaterial degradation

Alves MM · Marques LM · Nogueira I · Santos CF · Salazar SB · Eugénio S · Mira NP · Montemor MF

Applied Surface Science · 2018DOI →

Potential anti-cancer and anti-Candida activity of Zn-derived foams

Marques LM · Alves MM · Eugénio S · Salazar SB · Pedro NA · Grenho L · Mira NP · Fernandes MH · Montemor MF

Journal of Materials Chemistry B · 2018DOI →

Microstructured ZnO-rod like coating prevents biofilm formation prompted by pathogenic Candida spp.

Alves MM · Cunha DV · Santos CF · Mira NP · Montemor MF

Ceramics International · 2018DOI →

2017

The multidrug resistance transporters CgTpo1_1 and CgTpo1_2 play a role in virulence and biofilm formation in the human pathogen Candida glabrata

Santos R · Costa C · Mil-Homens D · Romão D · de Carvalho CCCR · Pais P · Mira NP · Fialho AM · Teixeira MC

Cellular Microbiology · 2017DOI →

Perspetivas mecanísticas subjacentes à tolerância ao stress por ácido acético em isolados vaginais de Candida glabrata

Cunha D, Salazar SB, Lopes MM, Mira NP.

Frontiers in Microbiology 8:259.DOI →

O regulão CgHaa1 medeia a resposta e tolerância ao stress por ácido acético no patogénio humano Candida glabrata

Bernardo R, Cunha DV, Wang C, Pereira L, Silva S, Salazar SB, Schroeder MS, Okamoto M, Takahashi-Nakaguchi A, Chibana H, Aoyoama T, Sá-Correia I, Azeredo J, Butler G, Mira NP.

G3: Genes, Genomes and Genetics 7:1-18.DOI →

2015

Genomic expression program of Saccharomyces cerevisiae along a mixed-culture wine fermentation with Hanseniaspora guilliermondii

Barbosa C · Mendes-Faia A · Lage P · Mira NP · Mendes-Ferreira A

Microbial Cell Factories · 2015DOI →

2014

Candida glabrata drug: H+ antiporter CgTpo3 (ORF CAGL0I10384g): role in azole drug resistance and polyamine homeostasis

Costa C · Nunes J · Henriques A · Mira NP · Nakayama H · Chibana H · Teixeira MC

Journal of Antimicrobial Chemotherapy · 2014DOI →